Biology:SLITRK5
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SLIT and NTRK-like protein 5 is a protein that in humans is encoded by the SLITRK5 gene.[1][2][3]
Function
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][3]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. December 1998. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ↑ "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene 315: 87–94. October 2003. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
- ↑ 3.0 3.1 "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26050.
Further reading
- "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)". Journal of Proteome Research 4 (5): 1661–71. 2006. doi:10.1021/pr050134h. PMID 16212419.
- "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Molecular and Cellular Neurosciences 24 (1): 117–29. September 2003. doi:10.1016/S1044-7431(03)00129-5. PMID 14550773.
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