Biology:SLITRK6
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SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.[1][2]
Function
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[1][2]
Clinical significance
Mutations in SLITRK6 cause high myopia and deafness in humans and mice.[3]
As a drug target
The protein is the target for the antibody-drug conjugate ASG-15ME which is in phase 1 clinical trials for urothelial cancer.[4]
References
- ↑ 1.0 1.1 "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene 315: 87–94. Oct 2003. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
- ↑ 2.0 2.1 "Entrez Gene: SLITRK6 SLIT and NTRK-like family, member 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84189.
- ↑ "SLITRK6 mutations cause myopia and deafness in humans and mice". J. Clin. Invest. 123 (5): 2094–102. 2013. doi:10.1172/JCI65853. PMID 23543054.
- ↑ Seattle Genetics and Agensys, an Affiliate of Astellas (October 2016). "Interim Analysis of a Phase 1 Dose Escalation Trial of ASG-22CE (ASG-22ME; enfortumab vedotin), an Antibody-Drug Conjugate (ADC) in Patients with Metastatic Urothelial Cancer". Poster Abstract #788P, European Society for Medical Oncology (ESMO) Congress, Copenhagen. http://www.businesswire.com/news/home/20161007005357/en/Seattle-Genetics-Agensys-Affiliate-Astellas-Highlight-Promising.
Further reading
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
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