Biology:SNX4
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 Generic protein structure example |
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[1][2]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[2]
Interactions
SNX4 has been shown to interact with BIN1.[3]
References
- ↑ "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. Dec 1998. doi:10.1128/mcb.18.12.7278. PMID 9819414.
- ↑ 2.0 2.1 "Entrez Gene: SNX4 sorting nexin 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8723.
- ↑ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. (England) 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.
Further reading
- "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.". Nat. Cell Biol. 9 (12): 1370–80. 2008. doi:10.1038/ncb1656. PMID 17994011.
- "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.". Traffic 8 (3): 297–309. 2007. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.". J. Cell Sci. 116 (Pt 10): 1937–48. 2004. doi:10.1242/jcs.00403. PMID 12668730.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332–9. 2001. doi:10.1074/jbc.M100606200. PMID 11279102.
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