Biology:SPINT2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.[1][2][3] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

References

  1. ↑ "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry 272 (18): 12202–8. May 1997. doi:10.1074/jbc.272.18.12202. PMID 9115294. 
  2. ↑ "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry 272 (44): 27558–64. Oct 1997. doi:10.1074/jbc.272.44.27558. PMID 9346890. 
  3. ↑ "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10653. 

Further reading

  • "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". European Journal of Biochemistry 221 (2): 881–8. Apr 1994. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643. 
  • "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". Journal of Immunological Methods 190 (1): 61–70. Mar 1996. doi:10.1016/0022-1759(95)00257-X. PMID 8601712. 
  • "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. Oct 1996. PMID 8895530. 
  • "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry 272 (10): 6370–6. Mar 1997. doi:10.1074/jbc.272.10.6370. PMID 9045658. 
  • "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". The Biochemical Journal 328 ( Pt 1) (Pt 1): 185–91. Nov 1997. doi:10.1042/bj3280185. PMID 9359851. 
  • "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1395 (1): 88–95. Jan 1998. doi:10.1016/s0167-4781(97)00129-2. PMID 9434156. 
  • "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". The Journal of Biological Chemistry 275 (51): 40453–62. Dec 2000. doi:10.1074/jbc.M006412200. PMID 11013244. 
  • "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochemical and Biophysical Research Communications 288 (2): 390–9. Oct 2001. doi:10.1006/bbrc.2001.5767. PMID 11606055. Bibcode: 2001BBRC..288..390I. 
  • "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". The Journal of Biological Chemistry 277 (10): 8022–32. Mar 2002. doi:10.1074/jbc.M108545200. PMID 11777908. 
  • "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade". European Journal of Biochemistry 269 (16): 3945–57. Aug 2002. doi:10.1046/j.1432-1033.2002.03068.x. PMID 12180971. 
  • "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases". Clinical Chemistry and Laboratory Medicine 40 (6): 579–86. Jun 2002. doi:10.1515/CCLM.2002.100. PMID 12211652. 
  • "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". Archives of Dermatological Research 294 (9): 387–92. Dec 2002. doi:10.1007/s00403-002-0336-9. PMID 12522575. 
  • "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis". Biological Chemistry 383 (12): 1953–7. Dec 2002. doi:10.1515/BC.2002.220. PMID 12553733. 
  • "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin". International Journal of Cancer 104 (3): 289–302. Apr 2003. doi:10.1002/ijc.10950. PMID 12569552. 
  • "Bikunin target genes in ovarian cancer cells identified by microarray analysis". The Journal of Biological Chemistry 278 (17): 14640–6. Apr 2003. doi:10.1074/jbc.M300239200. PMID 12571229. 
  • "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment". Journal of Neuro-Oncology 64 (3): 219–25. Sep 2003. doi:10.1023/A:1025674227750. PMID 14558597. 
  • "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma". Cancer Research 63 (24): 8674–9. Dec 2003. PMID 14695180. 
  • Overview of all the structural information available in the PDB for UniProt: O43291 (Kunitz-type protease inhibitor 2) at the PDBe-KB.




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