Biology:SPTBN5
From HandWiki
 Generic protein structure example |
Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.[1] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.
Structure and function
SPTBN5 contains the following domains:[1]
- actin-binding domain
- membrane-association domain-1
- self-association domain
- C-terminal pleckstrin homology domain.
Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.[1]
SPTBN5 is highly expressed in embryoid bodies.[2]
References
- ↑ 1.0 1.1 1.2 "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. July 2000. doi:10.1074/jbc.C000159200. PMID 10764729.
- ↑ "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. January 2009. doi:10.1021/pr8006667. PMID 19173612.
Further reading
- "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. 2008. doi:10.1074/jbc.M709729200. PMID 18048348.
- "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. 2010. doi:10.1038/ajh.2009.190. PMID 19851296.
- "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. 2002. doi:10.1006/cbir.2002.0895. PMID 12119179.
- "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science 260 (5112): 1338–43. 1993. doi:10.1126/science.8493579. PMID 8493579. Bibcode: 1993Sci...260.1338C.
 |
