Biology:SR1 RNA

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In molecular biology, the SR1 RNA is a small RNA (sRNA) produced by species of Bacillus and closely related bacteria.[1] It is a dual-function RNA which acts both as a protein-coding RNA and as a regulatory sRNA. SR1 RNA is involved in the regulation of arginine catabolism. SR1 RNA binds to complementary stretches of ahrC mRNA (also known as argR and inhibits translation.[2][3] AhrC endodes an arginine repressor protein which represses synthesis of arginine biosynthetic enzymes and activates arginine catabolic enzymes via regulation of the rocABC and rocDEF operons.[4][5][6]

In addition to acting as a sRNA, SR1 also encodes a small peptide, SR1P. SR1P binds to glyceraldehyde-3-phosphate dehydrogenase (GapA) and stabilises the gapA operon mRNAs.[7]

SR1 expression is regulated by CcpA and CcpN.[8][9]

See also

References

  1. ↑ "SR1—a small RNA with two remarkably conserved functions.". Nucleic Acids Research 40 (22): 11659–11672. October 13, 2012. doi:10.1093/nar/gks895. PMID 23034808. 
  2. ↑ "In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA.". Nucleic Acids Research 35 (13): 4331–4346. 2007. doi:10.1093/nar/gkm439. PMID 17576690. 
  3. ↑ "The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism.". Molecular Microbiology 62 (2): 520–536. October 2006. doi:10.1111/j.1365-2958.2006.05384.x. PMID 17020585. 
  4. ↑ "Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor.". Gene 80 (1): 29–38. August 1, 1989. doi:10.1016/0378-1119(89)90247-3. PMID 2507400. 
  5. ↑ "Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis". Mol. Microbiol. 6 (2): 267–275. January 1992. doi:10.1111/j.1365-2958.1992.tb02008.x. PMID 1312212. 
  6. ↑ "The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis.". Acta Crystallographica Section D 58 (Pt 3): 421–430. March 2002. doi:10.1107/s0907444901021692. PMID 11856827. 
  7. ↑ "A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon.". Molecular Microbiology 76 (4): 990–1009. May 2010. doi:10.1111/j.1365-2958.2010.07158.x. PMID 20444087. https://hal.archives-ouvertes.fr/hal-00552633/file/PEER_stage2_10.1111%252Fj.1365-2958.2010.07158.x.pdf. 
  8. ↑ "Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis.". Molecular Microbiology 58 (1): 189–206. October 2005. doi:10.1111/j.1365-2958.2005.04810.x. PMID 16164558. 
  9. ↑ "The transcriptional repressor CcpN from Bacillus subtilis uses different repression mechanisms at different promoters". Journal of Biological Chemistry 284 (44): 30032–30038. October 2009. doi:10.1074/jbc.M109.033076. PMID 19726675. 



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