Biology:SSX5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• "Molecular mechanisms underlying human synovial sarcoma development". Genes, Chromosomes & Cancer 30 (1): 1–14. January 2001. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170. 
• "SSX: a multigene family with several members transcribed in normal testis and human cancer". International Journal of Cancer 72 (6): 965–71. September 1997. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559. 
• "Expressions of cancer-testis antigens in human hepatocellular carcinomas". Cancer Letters 164 (2): 189–95. March 2001. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834. 
• "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer 34 (3): 285–98. July 2002. doi:10.1002/gcc.10073. PMID 12007189. 
• "The SSX gene family: characterization of 9 complete genes". International Journal of Cancer 101 (5): 448–53. October 2002. doi:10.1002/ijc.10634. PMID 12216073. 
• "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma". Life Sciences 79 (8): 744–8. July 2006. doi:10.1016/j.lfs.2006.02.024. PMID 16546222.