Biology:SUGT1
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Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.[1][2]
Function
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[2]
Interactions
SUGT1 has been shown to interact with S100A6.[3]
References
- ↑ "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell 4 (1): 21–33. July 1999. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
- ↑ 2.0 2.1 "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910.
- ↑ "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry 278 (29): 26923–8. July 2003. doi:10.1074/jbc.M211518200. PMID 12746458.
Further reading
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801.
- "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry 278 (29): 26923–8. July 2003. doi:10.1074/jbc.M211518200. PMID 12746458.
- "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence 14 (6): 436–41. December 2003. doi:10.1080/10425170310001623644. PMID 15018354.
- "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence 15 (2): 140–3. April 2004. doi:10.1080/1042517032000160215. PMID 15346769.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. January 2005. doi:10.1038/nbt1046. PMID 15592455.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. October 2006. doi:10.1038/nbt1240. PMID 16964243.
- "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America 104 (16): 6764–9. April 2007. doi:10.1073/pnas.0610926104. PMID 17420470. Bibcode: 2007PNAS..104.6764D.
- "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications 357 (4): 1148–53. June 2007. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.
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