Biology:SYBL1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Synaptobrevin-like protein 1 (SYBL1), also known as vesicle-associated membrane protein 7 (VAMP7), is a protein that in humans is encoded by the VAMP7, or SYBL1, gene.[1][2][3]
Function
SYBL1 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. SYBL1 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.[3]
Interactions
SYBL1 has been shown to interact with SNAP23[4][5] and AP3D1.[4]
References
- ↑ "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. Jul 1996. doi:10.1038/ng0696-227. PMID 8640232.
- ↑ "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. Jul 2001. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841.
- ↑ 3.0 3.1 "Entrez Gene: SYBL1 synaptobrevin-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6845.
- ↑ 4.0 4.1 "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. Jul 2003. doi:10.1073/pnas.1431910100. PMID 12853575. Bibcode: 2003PNAS..100.9011M.
- ↑ "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. Jun 1998. doi:10.1091/mbc.9.6.1437. PMID 9614185.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. 1998. doi:10.1091/mbc.9.6.1437. PMID 9614185.
- "VAMP-7 mediates vesicular transport from endosomes to lysosomes". J. Cell Biol. 146 (4): 765–76. 1999. doi:10.1083/jcb.146.4.765. PMID 10459012.
- "Human and mouse SYBL1 gene structure and expression". Gene 240 (1): 233–8. 1999. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831.
- "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. 2000. doi:10.1093/hmg/9.3.395. PMID 10655549.
- "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages". Mol. Biol. Cell 11 (7): 2327–33. 2000. doi:10.1091/mbc.11.7.2327. PMID 10888671.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863.
- "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. 2000. doi:10.1093/emboj/19.23.6453. PMID 11101518.
- "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. 2001. doi:10.1074/jbc.M010838200. PMID 11278762.
- "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. 2002. doi:10.1038/nsb746. PMID 11786915.
- "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. 2002. doi:10.1002/ajmg.10115. PMID 11840509.
- "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. 2002. doi:10.1042/BJ20020845. PMID 12175335.
- "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. 2002. doi:10.1093/hmg/11.25.3191. PMID 12444103.
- "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. 2003. doi:10.1073/pnas.1431910100. PMID 12853575. Bibcode: 2003PNAS..100.9011M.
- "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements". J. Biol. Chem. 279 (9): 7734–9. 2004. doi:10.1074/jbc.M308140200. PMID 14672948.
- "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. 2004. doi:10.1074/jbc.M400798200. PMID 14993220.
External links
- Overview of all the structural information available in the PDB for UniProt: P51809 (Vesicle-associated membrane protein 7) at the PDBe-KB.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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