Biology:SYTL2

Generic protein structure example

Synaptotagmin-like 2, also known as SYTL2, is a human gene.

Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.

Interactions

SYTL2 has been shown to interact with RAB27A.

Further reading

• "The C2 domain calcium-binding motif: structural and functional diversity". Protein Science 5 (12): 2375–90. December 1996. doi:10.1002/pro.5560051201. PMID 8976547. 
• "Double C2 protein. A review". Biochimie 82 (5): 421–6. May 2000. doi:10.1016/S0300-9084(00)00214-5. PMID 10865129. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. March 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. 
• "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (4): 273–81. August 2000. doi:10.1093/dnares/7.4.271. PMID 10997877. 
• "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins". Biochemical and Biophysical Research Communications 281 (5): 1226–33. March 2001. doi:10.1006/bbrc.2001.4512. PMID 11243866. 
• "Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain". Biochemical and Biophysical Research Communications 283 (2): 513–9. May 2001. doi:10.1006/bbrc.2001.4803. PMID 11327731. 
• "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–9. September 2001. doi:10.1006/geno.2001.6619. PMID 11543631. 
• "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry 277 (11): 9212–8. March 2002. doi:10.1074/jbc.M112414200. PMID 11773082. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry 278 (17): 15390–6. April 2003. doi:10.1074/jbc.M213090200. PMID 12590134. 
• "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. July 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. 
• "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• "Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain". Molecular Biology of the Cell 18 (2): 688–96. February 2007. doi:10.1091/mbc.E06-10-0914. PMID 17182843.