Biology:Signal peptidase II

From HandWiki
Signal peptidase II
Identifiers
EC number3.4.23.36
CAS number171715-14-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Signal peptidase II (EC 3.4.23.36, premurein-leader peptidase, prolipoprotein signal peptidase, leader peptidase II, premurein leader proteinase) is an enzyme.[1][2][3]

This enzyme catalyses a chemical reaction. It releases signal peptides from murein prolipoprotein and other bacterial membrane prolipoproteins. It also hydrolyses -Xaa-Yaa-Zaa-(S,diacylglyceryl)Cys-, in which Yaa (Ala or Ser) and Zaa (Gly or Ala) have small neutral sidechains, and Xaa is hydrophobic (preferably Leu).

This enzyme is present in bacterial inner membranes.

References

  1. "Signal peptidases and signal peptide hydrolases". Journal of Bioenergetics and Biomembranes 22 (3): 271–90. June 1990. doi:10.1007/bf00763168. PMID 2202720. 
  2. "Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene". FEBS Letters 299 (1): 80–4. March 1992. doi:10.1016/0014-5793(92)80105-p. PMID 1544479. 
  3. Bacterial prolipoprotein signal peptidase. Methods in Enzymology. 248. 1995. pp. 169–80. doi:10.1016/0076-6879(95)48014-5. 

External links