Biology:Synergin gamma
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Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.[1][2]
Function
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.[2]
Interactions
AP1GBP1 has been shown to interact with AP1G1[3][4] and SCAMP1.[5]
References
- ↑ "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. October 1999. doi:10.1083/jcb.146.5.993. PMID 10477754.
- ↑ 2.0 2.1 "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11276.
- ↑ "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. July 2002. doi:10.1038/nsb808. PMID 12042876.
- ↑ "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. May 2000. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- ↑ "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. April 2000. doi:10.1074/jbc.275.17.12752. PMID 10777571.
Further reading
- "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. 1998. doi:10.1006/geno.1998.5289. PMID 9653655.
- "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J. Cell Biol. 149 (1): 67–80. 2000. doi:10.1083/jcb.149.1.67. PMID 10747088.
- "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. 2000. doi:10.1074/jbc.275.17.12752. PMID 10777571.
- "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. 2000. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. 2002. doi:10.1038/nsb808. PMID 12042876.
- "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin". Structure 10 (8): 1139–48. 2002. doi:10.1016/S0969-2126(02)00801-8. PMID 12176391.
- "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. 2003. doi:10.1083/jcb.200208023. PMID 12538641.
- "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin". Mol. Biol. Cell 14 (6): 2385–98. 2003. doi:10.1091/mbc.E02-11-0735. PMID 12808037.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935.
- "The aftiphilin/p200/gamma-synergin complex". Mol. Biol. Cell 16 (5): 2554–65. 2005. doi:10.1091/mbc.E04-12-1077. PMID 15758025.
- "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Mol. Biol. Cell 16 (11): 5356–72. 2005. doi:10.1091/mbc.E05-07-0626. PMID 16162817.
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