Biology:AP1G1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.

Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

AP1G1 has been shown to interact with:

• AP1B1,
• AP1GBP1,
• AP1M1,
• AP1S1,
• NECAP2,
• RABEP1, and
• Synaptophysin.

Further reading

• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology 73 (2): 1350–61. Feb 1999. doi:10.1128/JVI.73.2.1350-1361.1999. PMID 9882340. 
• "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology 146 (5): 993–1004. Sep 1999. doi:10.1083/jcb.146.5.993. PMID 10477754. 
• "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. Oct 1999. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737. 
• "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology 149 (1): 67–80. Apr 2000. doi:10.1083/jcb.149.1.67. PMID 10747088. 
• "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications 271 (3): 719–25. May 2000. doi:10.1006/bbrc.2000.2700. PMID 10814529. 
• "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell 103 (4): 569–81. Nov 2000. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728. 
• "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter"]. Journal of Virology 75 (6): 2982–92. Mar 2001. doi:10.1128/JVI.75.6.2982-2992.2001. PMID 11222723. 
• "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". The EMBO Journal 20 (9): 2191–201. May 2001. doi:10.1093/emboj/20.9.2191. PMID 11331585. 
• "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochemical and Biophysical Research Communications 284 (4): 1083–9. Jun 2001. doi:10.1006/bbrc.2001.5081. PMID 11409905. 
• "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". The Journal of Biological Chemistry 276 (33): 31340–8. Aug 2001. doi:10.1074/jbc.M101054200. PMID 11418592. 
• "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Molecular Biology of the Cell 12 (7): 1925–35. Jul 2001. doi:10.1091/mbc.12.7.1925. PMID 11451993. 
• "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain". Journal of Biochemistry 131 (3): 327–36. Mar 2002. doi:10.1093/oxfordjournals.jbchem.a003107. PMID 11872161. 
• "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry 41 (14): 4669–77. Apr 2002. doi:10.1021/bi016064j. PMID 11926829. 
• "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry 277 (28): 25400–7. Jul 2002. doi:10.1074/jbc.M110793200. PMID 11950833. 
• "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology 9 (7): 527–31. Jul 2002. doi:10.1038/nsb808. PMID 12042876. 
• "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell 13 (11): 4060–73. Nov 2002. doi:10.1091/mbc.E02-03-0171. PMID 12429846. 

External links

• Human AP1G1 genome location and AP1G1 gene details page in the UCSC Genome Browser.