Biology:T-cell lymphoma invasion and metastasis-inducing protein 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.

Structure

TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

Function

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Interactions

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1, Myc, RAC1 and PPP1R9B.

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.

Further reading

• "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin". Oncogene 10 (7): 1371–1376. Apr 1995. PMID 7731688. 
• "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16". Cytogenetics and Cell Genetics 70 (1–2): 48–51. 1995. doi:10.1159/000133989. PMID 7736788. 
• "A role for Rac in Tiam1-induced membrane ruffling and invasion". Nature 375 (6529): 338–340. May 1995. doi:10.1038/375338a0. PMID 7753201. Bibcode: 1995Natur.375..338M. 
• "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–113. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation". The Journal of Cell Biology 137 (2): 387–398. Apr 1997. doi:10.1083/jcb.137.2.387. PMID 9128250. 
• "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". The Journal of Biological Chemistry 274 (18): 12753–12758. Apr 1999. doi:10.1074/jbc.274.18.12753. PMID 10212259. 
• "CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration". The Journal of Biological Chemistry 275 (3): 1829–1838. Jan 2000. doi:10.1074/jbc.275.3.1829. PMID 10636882. 
• "Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands". The Journal of Biological Chemistry 275 (33): 25751–25759. Aug 2000. doi:10.1074/jbc.M002050200. PMID 10835422. 
• "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". The Journal of Cell Biology 150 (1): 177–191. Jul 2000. doi:10.1083/jcb.150.1.177. PMID 10893266. 
• "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature 408 (6813): 682–688. Dec 2000. doi:10.1038/35047014. PMID 11130063. Bibcode: 2000Natur.408..682W. 
• "Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1". Proceedings of the National Academy of Sciences of the United States of America 98 (8): 4385–4390. Apr 2001. doi:10.1073/pnas.071411598. PMID 11274357. Bibcode: 2001PNAS...98.4385O. 
• "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry 276 (50): 47530–47541. Dec 2001. doi:10.1074/jbc.M108865200. PMID 11595749. 
• "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade". Molecular and Cellular Biology 22 (12): 4073–4085. Jun 2002. doi:10.1128/MCB.22.12.4073-4085.2002. PMID 12024021. 
• "Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism". Nature Cell Biology 4 (8): 621–625. Aug 2002. doi:10.1038/ncb833. PMID 12134164. 
• "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry 277 (49): 47810–47817. Dec 2002. doi:10.1074/jbc.M203816200. PMID 12376551. 
• "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry 278 (7): 5132–5140. Feb 2003. doi:10.1074/jbc.M206733200. PMID 12446731. 
• "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". The Journal of Biological Chemistry 278 (21): 18833–18841. May 2003. doi:10.1074/jbc.M207876200. PMID 12531897.