Biology:TACSTD2

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),[1] is a protein that in humans is encoded by the TACSTD2 gene.[2][3][4]

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[4]

This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.

References

  1. Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]
  2. "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol 13 (3): 1507–15. Apr 1993. doi:10.1128/MCB.13.3.1507. PMID 8382772. 
  3. "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet 92 (1–2): 164–5. Apr 2001. doi:10.1159/000056891. PMID 11306819. 
  4. 4.0 4.1 "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070. 

Further reading