Biology:TAF1A
 Generic protein structure example |
TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.[1][2]
Function
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[2]
Interactions
TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and Protein SET.[3]
References
- ↑ "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science 266 (5193): 1966–72. December 1994. doi:10.1126/science.7801123. PMID 7801123. Bibcode: 1994Sci...266.1966C.
- ↑ 2.0 2.1 "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015.
- ↑ 3.0 3.1 "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. January 2001. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
Further reading
- "TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription". EMBO J. 13 (11): 2611–6. 1994. doi:10.1002/j.1460-2075.1994.tb06551.x. PMID 8013460.
- "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. 2000. doi:10.1159/000015592. PMID 10894955.
- "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. 2000. doi:10.1128/MCB.20.16.5930-5938.2000. PMID 10913176.
- "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. 2001. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
- "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. 2001. doi:10.1093/emboj/20.6.1373. PMID 11250903.
- "The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors". J. Biochem. 135 (3): 429–38. 2004. doi:10.1093/jb/mvh051. PMID 15113842.
- "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. 2004. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
- "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. 2005. doi:10.1038/ncb1224. PMID 15723054.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
 |
