Biology:TAF7L

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.

Function

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Further reading

• "The role of the testis-specific gene hTAF7L in the aetiology of male infertility". Mol. Hum. Reprod. 12 (4): 263–7. April 2006. doi:10.1093/molehr/gal020. PMID 16597641. 
• "Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure". Andrologia 39 (5): 190–5. October 2007. doi:10.1111/j.1439-0272.2007.00789.x. PMID 17714218. 
• "Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern". Med. Oncol. 30 (1). March 2013. doi:10.1007/s12032-012-0368-8. PMID 23292864. 
• "Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers". Pathol. Oncol. Res. 21 (3): 849–50. July 2015. doi:10.1007/s12253-014-9832-4. PMID 25098277. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.