Biology:TCEAL1
 Generic protein structure example |
Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.[1][2][3]
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.[3]
References
- ↑ "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene 143 (2): 285–7. Jul 1994. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
- ↑ "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A 91 (23): 11002–6. Dec 1994. doi:10.1073/pnas.91.23.11002. PMID 7971997. Bibcode: 1994PNAS...9111002Y.
- ↑ 3.0 3.1 "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9338.
Further reading
- "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. 1995. doi:10.1074/jbc.270.44.26558. PMID 7592688.
- "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics 56 (2): 217–20. 1999. doi:10.1006/geno.1998.5705. PMID 10051408.
- "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. 1999. doi:10.1007/s001090050365. PMID 10353443.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Diseases of the Esophagus 18 (1): 37–40. 2005. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
- "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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