Biology:TFE3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.[1][2][3]
Function
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM][3]
Interactions
TFE3 has been shown to interact with:
- E2F3,[4]
- Microphthalmia-associated transcription factor,[5][6] and
- Mothers against decapentaplegic homolog 3[7][8]
Translocations
A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 PRCC
References
- ↑ "A high-frequency RFLP at the human TFE3 locus on the X chromosome". Nucleic Acids Res 19 (3): 684. May 1991. doi:10.1093/nar/19.3.684-a. PMID 1672758.
- ↑ "The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics 11 (2): 374–8. Feb 1992. doi:10.1016/0888-7543(91)90145-5. PMID 1685140.
- ↑ 3.0 3.1 "Entrez Gene: TFE3 transcription factor binding to IGHM enhancer 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7030.
- ↑ "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Mol. Cell. Biol. 23 (11): 3707–20. Jun 2003. doi:10.1128/mcb.23.11.3707-3720.2003. PMID 12748276.
- ↑ "Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4477–82. Apr 2002. doi:10.1073/pnas.072071099. PMID 11930005. Bibcode: 2002PNAS...99.4477S.
- ↑ "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. Feb 2002. PMID 11818452.
- ↑ "Both Max and TFE3 cooperate with Smad proteins to bind the plasminogen activator inhibitor-1 promoter, but they have opposite effects on transcriptional activity". J. Biol. Chem. 278 (13): 11227–36. Mar 2003. doi:10.1074/jbc.M211734200. PMID 12551947.
- ↑ "Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13130–5. Nov 1999. doi:10.1073/pnas.96.23.13130. PMID 10557285. Bibcode: 1999PNAS...9613130H.
Further reading
- "The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity". Genes Dev. 5 (6): 1057–66. 1991. doi:10.1101/gad.5.6.1057. PMID 2044953.
- "TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif". Genes Dev. 4 (2): 167–79. 1990. doi:10.1101/gad.4.2.167. PMID 2338243.
- "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. 1993. doi:10.1128/mcb.13.8.4505. PMID 8336698.
- "The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene". Hum. Mol. Genet. 5 (9): 1333–8. 1997. doi:10.1093/hmg/5.9.1333. PMID 8872474.
- "Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15294–8. 1997. doi:10.1073/pnas.93.26.15294. PMID 8986805.
- "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma". Oncogene 15 (18): 2233–9. 1997. doi:10.1038/sj.onc.1201394. PMID 9393982.
- "Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene". Genes Dev. 12 (19): 3084–95. 1998. doi:10.1101/gad.12.19.3084. PMID 9765209.
- "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development 125 (23): 4607–16. 1999. doi:10.1242/dev.125.23.4607. PMID 9806910.
- "Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13130–5. 1999. doi:10.1073/pnas.96.23.13130. PMID 10557285. Bibcode: 1999PNAS...9613130H.
- "Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins". Oncogene 19 (1): 69–74. 2000. doi:10.1038/sj.onc.1203255. PMID 10644981.
- "Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene". J. Biol. Chem. 275 (43): 33205–8. 2000. doi:10.1074/jbc.C000568200. PMID 10973944.
- "The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25". Oncogene 20 (1): 48–57. 2001. doi:10.1038/sj.onc.1204074. PMID 11244503.
- "Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes". Oncogene 20 (12): 1414–24. 2001. doi:10.1038/sj.onc.1204213. PMID 11313885.
- "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas". Cancer Res. 61 (10): 4130–5. 2001. PMID 11358836.
- "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry 40 (30): 8887–97. 2001. doi:10.1021/bi002847d. PMID 11467950.
- "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. 2002. doi:10.1074/jbc.M108417200. PMID 11748221.
- "bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins". J. Biol. Chem. 277 (13): 11375–84. 2002. doi:10.1074/jbc.M111284200. PMID 11801598.
- "Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4477–82. 2002. doi:10.1073/pnas.072071099. PMID 11930005. Bibcode: 2002PNAS...99.4477S.
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