Biology:E2F3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.

Interactions

E2F3 has been shown to interact with TFE3 and RYBP.

See also

• E2F

Further reading

• "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044. 
• "In vivo association of E2F and DP family proteins". Molecular and Cellular Biology 15 (5): 2536–46. May 1995. doi:10.1128/mcb.15.5.2536. PMID 7739537. 
• "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Molecular and Cellular Biology 16 (4): 1659–67. Apr 1996. doi:10.1128/mcb.16.4.1659. PMID 8657141. 
• "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proceedings of the National Academy of Sciences of the United States of America 93 (15): 7594–9. Jul 1996. doi:10.1073/pnas.93.15.7594. PMID 8755520. Bibcode: 1996PNAS...93.7594R. 
• "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". Journal of Cell Science 109 (7): 1717–26. Jul 1996. doi:10.1242/jcs.109.7.1717. PMID 8832394. 
• "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes & Development 10 (7): 851–61. Apr 1996. doi:10.1101/gad.10.7.851. PMID 8846921. 
• "The subcellular localization of E2F-4 is cell-cycle dependent". Proceedings of the National Academy of Sciences of the United States of America 94 (10): 5095–100. May 1997. doi:10.1073/pnas.94.10.5095. PMID 9144196. Bibcode: 1997PNAS...94.5095L. 
• "Specific regulation of E2F family members by cyclin-dependent kinases". Molecular and Cellular Biology 17 (7): 3867–75. Jul 1997. doi:10.1128/mcb.17.7.3867. PMID 9199321. 
• "Differential activities of E2F family members: unique functions in regulating transcription". Molecular Carcinogenesis 22 (3): 190–8. Jul 1998. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145. 
• "E2f3 is critical for normal cellular proliferation". Genes & Development 14 (6): 690–703. Mar 2000. doi:10.1101/gad.14.6.690. PMID 10733529. 
• "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes & Development 14 (7): 804–16. Apr 2000. doi:10.1101/gad.14.7.804. PMID 10766737. 
• "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins". Molecular and Cellular Biology 20 (10): 3626–32. May 2000. doi:10.1128/MCB.20.10.3626-3632.2000. PMID 10779352. 
• "Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region". Oncogene 19 (30): 3422–33. Jul 2000. doi:10.1038/sj.onc.1203682. PMID 10918599. 
• "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". European Journal of Biochemistry 268 (23): 6076–82. Dec 2001. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001. 
• "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes & Development 16 (2): 235–44. Jan 2002. doi:10.1101/gad.943102. PMID 11799066. 
• "E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints". Genes & Development 16 (2): 245–56. Jan 2002. doi:10.1101/gad.949802. PMID 11799067. 
• "E2F-3B is a physiological target of cyclin A". The Journal of Biological Chemistry 277 (26): 23493–9. Jun 2002. doi:10.1074/jbc.M202629200. PMID 11980909. 
• "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. Nov 2002. doi:10.1093/emboj/cdf577. PMID 12411495. 

External links

• E2F3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.