Biology:TICAM2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]

Further reading

• "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. 2007. doi:10.4049/jimmunol.178.7.4517. PMID 17372010. 
• "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. 2006. doi:10.1073/pnas.0510041103. PMID 16603631. 
• "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. 2003. doi:10.1038/ni986. PMID 14556004. 
• "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. 2004. doi:10.1074/jbc.M305820200. PMID 14519765. 
• "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. 2003. doi:10.1084/jem.20031023. PMID 14517278. 
• "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. 2003. doi:10.1038/sj.onc.1206406. PMID 12761501. 
• "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. 2003. doi:10.1074/jbc.M303451200. PMID 12721283. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. 2000. doi:10.1101/gr.10.5.703. PMID 10810093. 

External links

• Overview of all the structural information available in the PDB for UniProt: Q86XR7 (TIR domain-containing adapter molecule 2) at the PDBe-KB.