Biology:TIMP3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

See also

• TIMP1, TIMP2, TIMP4

Further reading

• "TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights.". Expert Reviews in Molecular Medicine 7 (24): 1–15. 2007. doi:10.1017/S1462399405010045. PMID 16259644. 
• "Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity". Nature 318 (6041): 66–9. 1985. doi:10.1038/318066a0. PMID 3903517. Bibcode: 1985Natur.318...66D. 
• "Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance.". Am. J. Ophthalmol. 94 (5): 634–49. 1983. doi:10.1016/0002-9394(82)90009-5. PMID 7148944. 
• "Structure of the human TIMP-3 gene and its cell cycle-regulated promoter.". Biochem. J.. 311 ( Pt 2) (2): 549–54. 1995. doi:10.1042/bj3110549. PMID 7487894. 
• "Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.". Nat. Genet. 11 (1): 27–32. 1995. doi:10.1038/ng0995-27. PMID 7550309. 
• "Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human endometrial stromal cells.". Endocrinology 136 (11): 4973–81. 1995. doi:10.1210/endo.136.11.7588231. PMID 7588231. 
• "Cloning and characterization of human tissue inhibitor of metalloproteinases-3.". DNA Cell Biol. 13 (7): 711–8. 1995. doi:10.1089/dna.1994.13.711. PMID 7772252. 
• "The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.". J. Biol. Chem. 270 (24): 14313–8. 1995. doi:10.1074/jbc.270.24.14313. PMID 7782289. 
• "Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix.". Matrix Biol. 14 (6): 479–88. 1995. doi:10.1016/0945-053X(95)90005-5. PMID 7795886. 
• "Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.". Nat. Genet. 8 (4): 352–6. 1995. doi:10.1038/ng1294-352. PMID 7894485. 
• "Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter.". Nat. Genet. 7 (2): 158–61. 1994. doi:10.1038/ng0694-158. PMID 7920634. 
• "Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa.". FEBS Lett. 352 (2): 171–4. 1994. doi:10.1016/0014-5793(94)00951-1. PMID 7925969. 
• "A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.". J. Biol. Chem. 269 (29): 18953–60. 1994. doi:10.1016/S0021-9258(17)32259-7. PMID 8034652. 
• "Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.". Gene 141 (2): 293–7. 1994. doi:10.1016/0378-1119(94)90588-6. PMID 8163205. 
• "Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.". Cancer Res. 54 (8): 2091–4. 1994. PMID 8174111. 
• "The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression.". Mol. Med. 1 (4): 418–27. 1996. doi:10.1007/BF03401579. PMID 8521299. 
• "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.". Hum. Mol. Genet. 4 (12): 2415–6. 1996. doi:10.1093/hmg/4.12.2415. PMID 8634721. 
• "Sorsby fundus dystrophy. A family with the Ser181Cys mutation of the tissue inhibitor of metalloproteinases 3.". Arch. Ophthalmol. 114 (6): 737–8. 1996. doi:10.1001/archopht.1996.01100130729016. PMID 8639088. 

External links

• The MEROPS online database for peptidases and their inhibitors: I35.003