Biology:TIP39
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.[1][2]
TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM][2]
The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [3]
References
- ↑ "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues". Endocrinology 143 (3): 1047–57. Feb 2002. doi:10.1210/endo.143.3.8698. PMID 11861531.
- ↑ 2.0 2.1 "Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113091.
- ↑ "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.". Biochemical Pharmacology 127: 71–81. 2017. doi:10.1016/j.bcp.2016.12.013. PMID 28012961.
Further reading
- "TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus.". Nat. Neurosci. 2 (11): 941–3. 1999. doi:10.1038/14724. PMID 10526330.
- "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. 2000. doi:10.1074/jbc.M003910200. PMID 10854439.
- "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1651–6. 2002. doi:10.1073/pnas.042416199. PMID 11818570. Bibcode: 2002PNAS...99.1651D.
- "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family.". J. Endocrinol. 174 (1): 95–102. 2002. doi:10.1677/joe.0.1740095. PMID 12098667.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor.". Neuropharmacology 44 (1): 141–53. 2003. doi:10.1016/S0028-3908(02)00335-0. PMID 12559132.
- "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation.". Eur. J. Pharmacol. 468 (3): 159–66. 2004. doi:10.1016/S0014-2999(03)01673-X. PMID 12754053.
- "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. 2004. doi:10.1210/me.2003-0487. PMID 14988434.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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