Biology:TM4SF5
 Generic protein structure example |
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1][2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[2]
References
- ↑ "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene 208 (1): 25–30. Mar 1998. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.
- ↑ 2.0 2.1 "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9032.
Further reading
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- Lee SY; Kim YT; Lee MS et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment". Exp. Cell Res. 312 (16): 2983–99. doi:10.1016/j.yexcr.2006.06.001. PMID 16828471.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Kaneko R; Tsuji N; Kamagata C et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". Am. J. Gastroenterol. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983.
- "The L6 membrane proteins--a new four-transmembrane superfamily". Protein Sci. 9 (8): 1594–600. 2000. doi:10.1110/ps.9.8.1594. PMID 10975581.
- Gress TM; Müller-Pillasch F; Geng M et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. PMID 8895530.
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