Biology:TREML1
From HandWiki
 Generic protein structure example |
Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.[1][2][3]
TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.
TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004).[supplied by OMIM][3]
References
- ↑ "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster". Blood 100 (10): 3822–4. Nov 2002. doi:10.1182/blood-2002-02-0523. PMID 12393607.
- ↑ "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur J Immunol 33 (2): 567–77. Mar 2003. doi:10.1002/immu.200310033. PMID 12645956.
- ↑ 3.0 3.1 "Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340205.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404.
- "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.". Blood 104 (4): 1042–7. 2005. doi:10.1182/blood-2004-01-0315. PMID 15100151.
- "Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.". J. Immunol. 172 (10): 5838–42. 2004. doi:10.4049/jimmunol.172.10.5838. PMID 15128762.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.". J. Biol. Chem. 281 (19): 13396–403. 2006. doi:10.1074/jbc.M600489200. PMID 16505478.
- "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.". Thromb. Haemost. 97 (6): 955–63. 2007. doi:10.1160/th06-08-0456. PMID 17549298. https://zenodo.org/record/1236186.
PDB gallery | |
|---|---|
|
 |
