Biology:TSC22D3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
TSC22 domain family protein 3 is a protein that in humans is encoded by the TSC22D3 gene.[1][2]
Function
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. GILZ shows ubiquitous expression across tissues, including thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle.[3][4] The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.[2]
Interactions
TSC22D3 has been shown to interact with C-Raf,[5] NFKB2[6] and NFKB1.[6]
References
- ↑ "hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1309 (3): 200–4. Dec 1996. doi:10.1016/s0167-4781(96)00177-7. PMID 8982256.
- ↑ 2.0 2.1 "Entrez Gene: TSC22D3 TSC22 domain family, member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1831.
- ↑ Ayyar, Vivaswath S.; Almon, Richard R.; Jusko, William J.; DuBois, Debra C. (2015-06-01). "Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids". Physiological Reports 3 (6): e12382. doi:10.14814/phy2.12382. PMID 26056061.
- ↑ Cannarile, L.; Zollo, O.; D'Adamio, F.; Ayroldi, E.; Marchetti, C.; Tabilio, A.; Bruscoli, S.; Riccardi, C. (2001-02-01). "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation 8 (2): 201–203. doi:10.1038/sj.cdd.4400798. ISSN 1350-9047. PMID 11313722.
- ↑ "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology 22 (22): 7929–41. Nov 2002. doi:10.1128/MCB.22.22.7929-7941.2002. PMID 12391160.
- ↑ 6.0 6.1 "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood 98 (3): 743–53. Aug 2001. doi:10.1182/blood.V98.3.743. PMID 11468175.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation 8 (2): 201–3. Feb 2001. doi:10.1038/sj.cdd.4400798. PMID 11313722.
- "Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ". The Journal of Biological Chemistry 276 (31): 29603–10. Aug 2001. doi:10.1074/jbc.M101522200. PMID 11397794.
- "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood 98 (3): 743–53. Aug 2001. doi:10.1182/blood.V98.3.743. PMID 11468175.
- "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology 22 (22): 7929–41. Nov 2002. doi:10.1128/MCB.22.22.7929-7941.2002. PMID 12391160.
- "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10". Blood 101 (2): 729–38. Jan 2003. doi:10.1182/blood-2002-02-0538. PMID 12393603.
- "A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells". EMBO Reports 4 (4): 374–80. Apr 2003. doi:10.1038/sj.embor.embor805. PMID 12671681.
- "GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis". Blood 104 (1): 215–23. Jul 2004. doi:10.1182/blood-2003-12-4295. PMID 15031210.
- "FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression". Molecular Endocrinology 19 (7): 1752–64. Jul 2005. doi:10.1210/me.2004-0206. PMID 15705665.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport". The Journal of Biological Chemistry 280 (48): 39970–81. Dec 2005. doi:10.1074/jbc.M508658200. PMID 16216878.
- "Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper". Blood 110 (1): 211–9. Jul 2007. doi:10.1182/blood-2006-10-052506. PMID 17356131.
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