Biology:TSEN15
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 Generic protein structure example |
tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.[1][2][3]
tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][3]
Interactions
C1orf19 has been shown to interact with TSEN2.[4]
References
- ↑ "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics 73 (2): 211–22. April 2001. doi:10.1006/geno.2001.6500. PMID 11318611. https://zenodo.org/record/1229806.
- ↑ "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology 366 (1): 155–64. February 2007. doi:10.1016/j.jmb.2006.11.024. PMID 17166513.
- ↑ 3.0 3.1 "Entrez Gene: C1orf19 chromosome 1 open reading frame 19". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116461.
- ↑ "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell 117 (3): 311–21. April 2004. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
Further reading
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. July 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. July 2004. doi:10.1101/gr.2122004. PMID 15231747.
- "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell 117 (3): 311–21. April 2004. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
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