Biology:TSPY1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.[1]
The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mice. Two transcript variants encoding different isoforms have been found for this gene.[2] The protein is strongly overexpressed in gonadoblastoma.[3]
See also
- TSPYL1: TSPY1 like protein
References
- ↑ "Entrez Gene: TSPY1 Testis specific protein, Y-linked 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7258.
- ↑ "TSPY1 testis specific protein Y-linked 1 [Homo sapiens (human)] - Gene - NCBI". https://www.ncbi.nlm.nih.gov/gene/7258.
- ↑ "Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues.". Hum. Mol. Genet. 5 (11): 1801–7. 1997. doi:10.1093/hmg/5.11.1801. PMID 8923009.
Further reading
- "Human male fertility--Y-linked genes and spermatogenesis.". Hum. Mol. Genet.. 3 Spec No: 1449–52. 1995. doi:10.1093/hmg/3.suppl_1.1449. PMID 7849736.
- "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein".". Cytogenet. Cell Genet. 80 (1–4): 209–13. 1998. doi:10.1159/000014982. PMID 9678360.
- Lau YF (2000). "Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.". Am. J. Hum. Genet. 64 (4): 921–7. doi:10.1086/302353. PMID 10090875.
- "Molecular isolation and characterization of an expressed gene from the human Y chromosome.". Hum. Mol. Genet. 1 (9): 717–26. 1993. doi:10.1093/hmg/1.9.717. PMID 1284595.
- "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY.". Genomics 11 (1): 108–14. 1992. doi:10.1016/0888-7543(91)90107-P. PMID 1765369.
- "A human Y-chromosomal DNA sequence expressed in testicular tissue.". Nucleic Acids Res. 15 (21): 8713–24. 1988. doi:10.1093/nar/15.21.8713. PMID 3479749.
- "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.". Genomics 17 (3): 726–31. 1993. doi:10.1006/geno.1993.1393. PMID 8244388.
- "A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny.". Am. J. Phys. Anthropol. 100 (3): 301–9. 1996. doi:10.1002/(SICI)1096-8644(199607)100:3<301::AID-AJPA1>3.0.CO;2-X. PMID 8798990.
- "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997.". Cytogenet. Cell Genet. 79 (1–2): 1–20. 1998. doi:10.1159/000134680. PMID 9533010.
- "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family.". Cytogenet. Cell Genet. 81 (3–4): 265–70. 1998. doi:10.1159/000015042. PMID 9730615.
- "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. 2000. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295.
- "Characterization of a new TSPY gene family member in Yq (TSPYq1).". Cytogenet. Cell Genet. 88 (1–2): 159–62. 2000. doi:10.1159/000015510. PMID 10773691.
- "TSPY variants in six loci on the human Y chromosome.". Cytogenet. Cell Genet. 91 (1–4): 67–71. 2001. doi:10.1159/000056821. PMID 11173833.
- "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma.". Cytogenet. Cell Genet. 91 (1–4): 160–4. 2001. doi:10.1159/000056838. PMID 11173850.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes.". Gene 302 (1–2): 11–9. 2003. doi:10.1016/S0378-1119(02)01104-6. PMID 12527192.
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