Biology:TTRAP
Transforming growth factor-β (TGF-β) principally relays its effects through the Smad pathway however, accumulating evidence indicate that alternative signalling routes are also employed by this pleiotropic cytokine. For instance recently, we [?] have demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module, resulting in MAP kinase activation. Here we report identification of the adaptor molecule TTRAP as a novel component of this non-canonical TGF-β pathway. We show that the protein associates with TGF-β receptors and components of the TRAF6-TAK1 signaling module, resulting in differential regulation of TGF-β activated p38 and NF-κB responses. Modulation of cellular TTRAP level affects cell viability in the presence of TGF-β, suggesting that the protein is an important component of the TGF-β induced apoptotic process.
Interactions
TTRAP has been shown to interact with ETS1,[1] TNFRSF1B[2] and CD40.[2]
References
Further reading
- "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. 2000. doi:10.1074/jbc.M000531200. PMID 10764746.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. 2003. doi:10.1038/sj.onc.1206374. PMID 12743594.
- "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. 2003. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Interactions
TTRAP has been shown to interact with ETS1,[1] TNFRSF1B[2] and CD40.[2]
References
Further reading
- "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. 2000. doi:10.1074/jbc.M000531200. PMID 10764746.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. 2003. doi:10.1038/sj.onc.1206374. PMID 12743594.
- "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. 2003. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Function
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.[3]
Interactions
TTRAP has been shown to interact with ETS1,[1] TNFRSF1B[2] and CD40.[2]
References
- ↑ 1.0 1.1 1.2 "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. May 2003. doi:10.1038/sj.onc.1206374. PMID 12743594.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. June 2000. doi:10.1074/jbc.M000531200. PMID 10764746.
- ↑ "Entrez Gene: TTRAP TRAF and TNF receptor associated protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51567.
Further reading
- "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. 2000. doi:10.1074/jbc.M000531200. PMID 10764746.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. 2003. doi:10.1038/sj.onc.1206374. PMID 12743594.
- "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. 2003. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability". Biol. Psychiatry 62 (7): 811–7. 2007. doi:10.1016/j.biopsych.2007.03.007. PMID 17597587.
 |  |
