Biology:TXNDC5

Generic protein structure example

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.

Function

This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.

Further reading

• "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research 288 (1): 70–83. Aug 2003. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160. 
• "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics 2 (10): 1104–19. Oct 2003. doi:10.1074/mcp.M300053-MCP200. PMID 12930873. 
• "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry 278 (47): 47079–88. Nov 2003. doi:10.1074/jbc.M308124200. PMID 12963716. 
• "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. Oct 2005. doi:10.1002/pmic.200401239. PMID 16130169. 
• "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters 580 (9): 2216–26. Apr 2006. doi:10.1016/j.febslet.2006.03.029. PMID 16574106. 
• "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine 232 (9): 1152–9. Oct 2007. doi:10.3181/0701-RM-8. PMID 17895523.