Biology:Tight junction protein 2

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Generic protein structure example

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.[1]

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].[2]

Interactions

Tight junction protein 2 has been shown to interact with tight junction protein 1,[3][4][5] band 4.1,[6] occludin[3][4][7] and USP53.[8]

References

  1. "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet 3 (6): 909–914. November 1994. doi:10.1093/hmg/3.6.909. PMID 7951235. 
  2. "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9414. 
  3. 3.0 3.1 Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. ISSN 0021-9258. PMID 10026224. 
  4. 4.0 4.1 Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001. 
  5. Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. 273 (45): 29745–29753. doi:10.1074/jbc.273.45.29745. ISSN 0021-9258. PMID 9792688. 
  6. Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. ISSN 0021-9258. PMID 10874042. 
  7. Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis". J. Biol. Chem. 278 (49): 49644–49651. doi:10.1074/jbc.M302782200. ISSN 0021-9258. PMID 14512431. 
  8. "Progressive Hearing Loss in Mice Carrying a Mutation in Usp53". The Journal of Neuroscience 35 (47): 15582–98. November 2015. doi:10.1523/JNEUROSCI.1965-15.2015. PMID 26609154. 

Further reading