Biology:Time-resolved mass spectrometry

From HandWiki

Time-resolved mass spectrometry (TRMS) is a strategy in analytical chemistry that uses mass spectrometry platform to collect data with temporal resolution.[1][2][3] Implementation of TRMS builds on the ability of mass spectrometers to process ions within sub-second duty cycles. It often requires the use of customized experimental setups. However, they can normally incorporate commercial mass spectrometers. As a concept in analytical chemistry, TRMS encompasses instrumental developments (e.g. interfaces, ion sources, mass analyzers), methodological developments, and applications.

Applications

An early application of TRMS was in the observation of flash photolysis process.[4] It took advantage of a time-of-flight mass analyzer.[5] TRMS currently finds applications in the monitoring of organic reactions,[6] formation of reactive intermediates,[7] enzyme-catalyzed reactions,[8] convection,[9] protein folding,[10] extraction,[11] and other chemical and physical processes.

Temporal resolution

TRMS is typically implemented to monitor processes that occur on second to millisecond time scale. However, there exist reports from studies in which sub-millisecond resolutions were achieved.[4][5][6]

References

  1. ↑ Urban P.L., Chen Y.-C., Wang Y.-S. 2016, Time-Resolved Mass Spectrometry: From Concept to Applications. Wiley, Chichester, ISBN:978-1-118-88732-5, http://as.wiley.com/WileyCDA/WileyTitle/productCd-1118887328.html
  2. ↑ Chen, Yu-Chie; Urban, Pawel L. (2013). "Time-resolved mass spectrometry". TrAC Trends in Analytical Chemistry 44: 106–20. doi:10.1016/j.trac.2012.11.010. 
  3. ↑ Rob, Tamanna; Wilson, Derek (2012). "Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processes". European Journal of Mass Spectrometry 18 (2): 205–14. doi:10.1255/ejms.1176. PMID 22641726. 
  4. ↑ 4.0 4.1 Meyer, Richard T. (1967). "Flash Photolysis and Time‐Resolved Mass Spectrometry. I. Detection of the Hydroxyl Radical". The Journal of Chemical Physics 46 (3): 967–972. doi:10.1063/1.1840834. Bibcode: 1967JChPh..46..967M. 
  5. ↑ 5.0 5.1 "Apparatus for flash photolysis and time resolved mass spectrometry". http://iopscience.iop.org/0950-7671/44/6/303. Retrieved 27 January 2014. 
  6. ↑ 6.0 6.1 Miao, Zhixin; Chen, Hao; Liu, Pengyuan; Liu, Yan (2011). "Development of Submillisecond Time-Resolved Mass Spectrometry Using Desorption Electrospray Ionization". Analytical Chemistry 83 (11): 3994–7. doi:10.1021/ac200842e. PMID 21539335. 
  7. ↑ Perry, Richard H.; Splendore, Maurizio; Chien, Allis; Davis, Nick K.; Zare, Richard N. (2011). "Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization". Angewandte Chemie International Edition 50 (1): 250–4. doi:10.1002/anie.201004861. PMID 21110361. 
  8. ↑ Ting, Hsu; Urban, Pawel L. (2014). "Spatiotemporal effects of a bioautocatalytic chemical wave revealed by time-resolved mass spectrometry". RSC Advances 4 (5): 2103–8. doi:10.1039/C3RA42873G. Bibcode: 2014RSCAd...4.2103T. 
  9. ↑ Li, Po-Han; Ting, Hsu; Chen, Yu-Chie; Urban, Pawel L. (2012). "Recording temporal characteristics of convection currents by continuous and segmented-flow sampling". RSC Advances 2 (32): 12431–7. doi:10.1039/C2RA21695G. Bibcode: 2012RSCAd...212431L. https://ir.nctu.edu.tw:443/bitstream/11536/20902/1/000312148500058.pdf. 
  10. ↑ Breuker, K.; McLafferty, F. W. (2008). "Stepwise evolution of protein native structure with electrospray into the gas phase, 10-12 to 102 s". Proceedings of the National Academy of Sciences 105 (47): 18145–52. doi:10.1073/pnas.0807005105. PMID 19033474. Bibcode: 2008PNAS..10518145B. 
  11. ↑ Hu, J.-B.; Chen, S.-Y.; Wu, J.-T.; Chen, Y.-C.; Urban, P L. (2014). "Automated system for extraction and instantaneous analysis of millimeter-sized samples". RSC Advances 4 (21): 10693–10701. doi:10.1039/C3RA48023B. Bibcode: 2014RSCAd...410693H. 



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