Biology:Transcriptional activator LAG-3
From HandWiki
| Activator_LAG-3 | |||||||||
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 crystal structure of the csl-notch-mastermind ternary complex bound to dna | |||||||||
| Identifiers | |||||||||
| Symbol | Activator_LAG-3 | ||||||||
| Pfam | PF11498 | ||||||||
| InterPro | IPR021587 | ||||||||
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In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12.[1] Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1.[1]
References
- ↑ 1.0 1.1 "LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway". Nature 405 (6784): 364–8. May 2000. doi:10.1038/35012645. PMID 10830967. Bibcode: 2000Natur.405..364P.
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