Biology:Transmembrane protein 44
 Generic protein structure example |
Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene. [1]
Gene
mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.[2]
Locus
TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens).[3]
Protein
TMEM44 is 428 amino acids in length. The molecular weight of the protein is 47.1kDa, and its formula is C2086H3315N585O611S22, with a total of 6619 atoms.[4] TMEM44 is predicted to be integrated in the plasma membrane of the endoplasmic reticulum.
Expression
There is an overall low level expression of TMEM44 protein throughout the developmental stages of an organism.[5]
Transcripts
There are 12 isoforms of TMEM44 including isoform a, isoform b, isoform c, isoform d, isoform X1, isoform X2, isoform X3, isoform X4, isoform X5, isoform X6, isoform X7, isoform X8.[3]
Transmembrane Region Allocation
There are seven predicted transmembrane domains in TMEM44 protein.
Interacting Proteins
GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.[6][7][8]
Post-Translational Modification
TMEM44 is predicted to undergo threonine, tyrosine and serine phosphorylations.[9]
Orthologs
TMEM44 orthologs includes groups such as amphibians, birds, fish, mammals.[10]
Paralogs
Predicted paralogous proteins of TMEM44 are C9IZ85, F8WCY1, F8WE47, H7C3X7, J3KQW3, Q6PL43, and Q96I73.[11]
References
- ↑ "Entrez Gene: Transmembrane protein 44". https://www.ncbi.nlm.nih.gov/gene/93109. Retrieved 2018-05-01.
- ↑ Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI. 16 March 2005. https://www.ncbi.nlm.nih.gov/nuccore/BC034353.1?report=genbank. Retrieved 2018-02-18.
- ↑ 3.0 3.1 "TMEM44 transmembrane protein 44 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene?term=(tmem44%5Bgene%5D)%20AND%20(Homo%20sapiens%5Borgn%5D)%20AND%20alive%5Bprop%5D%20NOT%20newentry%5Bgene%5D&sort=weight.
- ↑ "ExPASy - ProtParam tool" (in en-US). https://web.expasy.org/protparam/.
- ↑ Group, Schuler. "EST Profile - Hs.478729". https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.478729.
- ↑ IntAct. "IntAct Portal" (in en). https://www.ebi.ac.uk/intact/.
- ↑ Lab, Mike Tyers. "BioGRID | Database of Protein, Chemical, and Genetic Interactions" (in en). https://thebiogrid.org/.
- ↑ "The Molecular INTeraction Database – An ELIXIR Core Resource" (in en-US). https://mint.bio.uniroma2.it/.
- ↑ "NetPhos 3.1 Server" (in en). http://www.cbs.dtu.dk/services/NetPhos/.
- ↑ "BLAST: Basic Local Alignment Search Tool". https://blast.ncbi.nlm.nih.gov/Blast.cgi.
- ↑ Database, GeneCards Human Gene. "TMEM44 Gene - GeneCards | TMM44 Protein | TMM44 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=TMEM44#paralogs.
Further reading
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