Biology:Trimethylamine-N-oxide reductase (cytochrome c)
From HandWiki
| trimethylamine-N-oxide reductase (cytochrome c) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.7.2.3 | ||||||||
| CAS number | 37256-34-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a trimethylamine-N-oxide reductase (cytochrome c) (EC 1.7.2.3) is an enzyme that catalyzes the chemical reaction
- trimethylamine + 2 (ferricytochrome c)-subunit + H2O [math]\displaystyle{ \rightleftharpoons }[/math] trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+
The 3 substrates of this enzyme are trimethylamine, (ferricytochrome c)-subunit, and H2O, whereas its 3 products are trimethylamine N-oxide, (ferrocytochrome c)-subunit, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with a cytochrome as acceptor. The systematic name of this enzyme class is trimethylamine:cytochrome c oxidoreductase. Other names in common use include TMAO reductase, and TOR. This enzyme participates in two-component system - general.
References
- "Purification and properties of trimethylamine N-oxide reductase from aerobic photosynthetic bacterium Roseobacter denitrificans". J. Biochem. (Tokyo) 112 (4): 470–5. October 1992. PMID 1337081.
- "Isolation, cloning, sequence analysis and X-ray structure of dimethyl sulfoxide/trimethylamine N-oxide reductase from Rhodobacter capsulatus". Biol. Chem. 378 (3–4): 293–302. 1997. doi:10.1515/bchm.1997.378.3-4.293. PMID 9165084.
- "Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution". J. Mol. Biol. 284 (2): 435–47. 1998. doi:10.1006/jmbi.1998.2156. PMID 9813128.
- "Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli". J. Biol. Chem. 276 (15): 11545–51. 2001. doi:10.1074/jbc.M008875200. PMID 11056172.
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