Biology:Trnp1
TMF regulated nuclear protein 1 is a nuclear protein with a crucial role in cellular proliferation and brain development.[1] Trnp1 is the first protein that has been shown to play a major role in cortical folding.[1] It represents a major stem cell factor, that is involved in crucial processes during brain but also stem cell development. Trnp1 controls gene expression levels and is sufficient to induce gyri and sulci in the developing brain. Local differences of Trnp1 expression levels in the human brain correlate with cortical folding.[1][2][3] Additionally, there are hints suggesting that Trnp1 might play a role in cancer, e. g. Trnp1 dramatically increases the proliferation rate in vitro an in vivo and has also been described in gene expression analysis in cancer cells.
References
- ↑ 1.0 1.1 1.2 Stahl, Ronny; Walcher, Tessa; De Juan Romero, Camino; Pilz, Gregor Alexander; Cappello, Silvia; Irmler, Martin; Sanz-Aquela, José Miguel; Beckers, Johannes et al. (2013-04-25). "Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate" (in English). Cell 153 (3): 535–549. doi:10.1016/j.cell.2013.03.027. ISSN 0092-8674. PMID 23622239. http://www.cell.com/cell/abstract/S0092-8674(13)00349-8.
- ↑ Fernández, Virginia; Llinares‐Benadero, Cristina; Borrell, Víctor (2016-04-07). "Cerebral cortex expansion and folding: what have we learned?" (in en). The EMBO Journal: e201593701. doi:10.15252/embj.201593701. ISSN 0261-4189. PMID 27056680. PMC 4868950. http://emboj.embopress.org/content/early/2016/04/07/embj.201593701.
- ↑ Martínez-Martínez, Maria Ángeles; Romero, Camino De Juan; Fernández, Virginia; Cárdenas, Adrián; Götz, Magdalena; Borrell, Víctor (2016-06-06). "A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels" (in en). Nature Communications 7. doi:10.1038/ncomms11812. ISSN 2041-1723. PMID 27264089. PMC 4897765. https://www.nature.com/articles/ncomms11812.
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