Biology:UCN2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.[1][2]
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[2]
References
- ↑ "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med 7 (5): 605–11. Apr 2001. doi:10.1038/87936. PMID 11329063.
- ↑ 2.0 2.1 "Entrez Gene: UCN2 urocortin 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=90226.
Further reading
- "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands.". Pharmacol. Rev. 55 (1): 21–6. 2003. doi:10.1124/pr.55.1.3. PMID 12615952.
- "Human endometrium expresses urocortin II and III messenger RNA and peptides.". Fertil. Steril. 86 (6): 1766–70. 2006. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
- "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes.". Am. J. Obstet. Gynecol. 195 (1): 288–95. 2006. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
- "Modifications of the human urocortin 2 peptide that improve pharmacological properties.". Peptides 27 (7): 1806–13. 2006. doi:10.1016/j.peptides.2006.01.003. PMID 16476507.
- "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats.". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. 2006. doi:10.1152/ajpgi.00289.2005. PMID 16223946.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Ancient evolution of stress-regulating peptides in vertebrates.". Peptides 25 (10): 1681–8. 2005. doi:10.1016/j.peptides.2004.05.022. PMID 15476935.
- "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.". Endocrinology 145 (2): 890–900. 2004. doi:10.1210/en.2003-1210. PMID 14592950.
- "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.". J. Mol. Cell. Cardiol. 35 (10): 1295–305. 2004. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. 2001. doi:10.1073/pnas.121165198. PMID 11416224. Bibcode: 2001PNAS...98.7570L.
- "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. 2001. doi:10.1073/pnas.051626398. PMID 11226328. Bibcode: 2001PNAS...98.2843R.
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