Biology:UNC93A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[1]
Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[2][3] It belongs to the atypical SLCs that was recently listed.[2] It is therefore presumed that UNC93A is a transporter protein.
UNC93A is closely related to UNC93B1 and MFSD11.[4][5]
UNC93A is affected by amino acid deprivation in cell cortex cultures[3][4] and starvation in in vivo samples.[4]
It is expressed in neurons, with staining close to the plasma membrane.[4]
Read also [6][7] for functional studies in C.elegans.
For you who are interested to read more about Unc93A in different species, see: [8]
References
- ↑ "Entrez Gene: Unc-93 homolog A (C. elegans)". https://www.ncbi.nlm.nih.gov/gene/54346.
- ↑ 2.0 2.1 "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences 38 (3): 305–315. March 2017. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
- ↑ 3.0 3.1 "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology 7 (9): 170142. September 2017. doi:10.1098/rsob.170142. PMID 28878041.
- ↑ 4.0 4.1 4.2 4.3 "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice" (in English). Frontiers in Molecular Neuroscience 10: 351. 2017. doi:10.3389/fnmol.2017.00351. PMID 29163028.
- ↑ "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE 11 (6): e0156912. 2016. doi:10.1371/journal.pone.0156912. PMID 27272503. Bibcode: 2016PLoSO..1156912P.
- ↑ "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology 117 (1): 143–55. April 1992. doi:10.1083/jcb.117.1.143. PMID 1313436.
- ↑ "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience 23 (27): 9133–45. October 2003. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMID 14534247.
- ↑ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A" (in English). Frontiers in Cell and Developmental Biology 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMID 33163493.
Further reading
- "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics 3: 20. October 2002. doi:10.1186/1471-2156-3-20. PMID 12381271.
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