Biology:USF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[1][2]
Function
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
Interactions
USF2 has been shown to interact with USF1 (human gene),[3][4] PPRC1[5] and BRCA1.[6]
Regulation
The USF2 gene is repressed by the microRNA miR-10a.[7]
References
- ↑ "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics 38 (2): 141–8. Dec 1996. doi:10.1006/geno.1996.0609. PMID 8954795.
- ↑ 2.0 2.1 "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7392.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1). 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry 271 (3): 1405–15. Jan 1996. doi:10.1074/jbc.271.3.1405. PMID 8576131.
- ↑ "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry 278 (19): 17263–8. May 2003. doi:10.1074/jbc.M210486200. PMID 12611894.
- ↑ "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis 38 (2): 85–96. Oct 2003. doi:10.1002/mc.10148. PMID 14502648. https://zenodo.org/record/1229285.
- ↑ "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research 6 (12): 1830–40. Dec 2008. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.
Further reading
- "[USF as a key regulatory element of gene expression"]. Médecine/Sciences 22 (1): 62–7. Jan 2006. doi:10.1051/medsci/200622162. PMID 16386222. http://www.erudit.org/fr/revues/ms/2006-v22-n1-ms1037/012233ar.pdf.
- "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers". Gene Expression 2 (3): 231–40. 1993. PMID 1450663.
- "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos". Science 256 (5059): 1014–8. May 1992. doi:10.1126/science.1589769. PMID 1589769. Bibcode: 1992Sci...256.1014B.
- "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry 271 (3): 1405–15. Jan 1996. doi:10.1074/jbc.271.3.1405. PMID 8576131.
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene 14 (5): 589–94. Feb 1997. doi:10.1038/sj.onc.1200866. PMID 9053857.
- "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications 231 (2): 333–9. Feb 1997. doi:10.1006/bbrc.1997.6097. PMID 9070273. Bibcode: 1997BBRC..231..333K.
- "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2". The Journal of Biological Chemistry 272 (16): 10538–42. Apr 1997. doi:10.1074/jbc.272.16.10538. PMID 9099698.
- "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level". Blood 89 (8): 2999–3008. Apr 1997. doi:10.1182/blood.V89.8.2999. PMID 9108421.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300". Biochimica et Biophysica Acta (BBA) - General Subjects 1428 (2–3): 169–76. Aug 1999. doi:10.1016/s0304-4165(99)00061-6. PMID 10434034.
- "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome". The Journal of Biological Chemistry 276 (6): 4357–64. Feb 2001. doi:10.1074/jbc.M009629200. PMID 11058604.
- "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia". Haematologia 31 (2): 125–38. 2002. doi:10.1163/15685590152492936. PMID 11583024.
- "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal 365 (Pt 2): 481–8. Jul 2002. doi:10.1042/BJ20020223. PMID 11945176.
- "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis 32 (4): 247–58. Apr 2002. doi:10.1002/gene.10078. PMID 11948912.
- "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry 278 (19): 17263–8. May 2003. doi:10.1074/jbc.M210486200. PMID 12611894.
- "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology 65 (7): 1087–96. Apr 2003. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.
- "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood 102 (7): 2420–7. Oct 2003. doi:10.1182/blood-2003-01-0251. PMID 12791656.
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