Biology:VAV2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[1][2]
VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[2]
Interactions
VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.[3] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1[3] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.[3] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner[4] and interact with CD19[5] and Grb2.[6][7]
References
- ↑ "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet 59 (Pt 1): 25–37. June 1995. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982.
- ↑ 2.0 2.1 "Entrez Gene: VAV2 vav 2 oncogene". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7410.
- ↑ 3.0 3.1 3.2 Marignani, Paola A; Kanai, Fumihiko (2001-07-09). "Vav2 is required for cell spreading" (in en). The Journal of Cell Biology 154 (1): 177–186. doi:10.1083/jcb.200103134. ISSN 0021-9525. PMID 11448999.
- ↑ Arora, P. D.; Marignani, P. A.; McCulloch, C. A. (July 2008). "Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2" (in en). American Journal of Physiology. Cell Physiology 295 (1): C130–C137. doi:10.1152/ajpcell.00168.2008. ISSN 0363-6143. PMID 18434624.
- ↑ Doody, G M; Billadeau D D; Clayton E; Hutchings A; Berland R; McAdam S; Leibson P J; Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMID 11080163.
- ↑ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067.
- ↑ Bourguignon, L Y; Zhu H; Zhou B; Diedrich F; Singleton P A; Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.
Further reading
- "Structure and function of vav.". Cell. Signal. 8 (8): 545–53. 1997. doi:10.1016/S0898-6568(96)00118-0. PMID 9115846.
- "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors.". J. Biol. Chem. 271 (15): 8564–9. 1996. doi:10.1074/jbc.271.15.8564. PMID 8621483.
- "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.". Blood 90 (4): 1588–93. 1997. doi:10.1182/blood.V90.4.1588. PMID 9269777.
- "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. 1999. doi:10.1093/emboj/18.4.904. PMID 10022833.
- "Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors.". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 179–84. 2000. doi:10.1073/pnas.97.1.179. PMID 10618391. Bibcode: 2000PNAS...97..179P.
- "Vav family proteins couple to diverse cell surface receptors.". Mol. Cell. Biol. 20 (17): 6364–73. 2000. doi:10.1128/MCB.20.17.6364-6373.2000. PMID 10938113.
- "Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins.". Mol. Cell. Biol. 20 (19): 7160–9. 2000. doi:10.1128/MCB.20.19.7160-7169.2000. PMID 10982832.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes.". EMBO J. 19 (22): 6173–84. 2001. doi:10.1093/emboj/19.22.6173. PMID 11080163.
- "Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte.". J. Biol. Chem. 276 (24): 20849–57. 2001. doi:10.1074/jbc.M010588200. PMID 11262396.
- "c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases.". Oncogene 20 (14): 1739–55. 2001. doi:10.1038/sj.onc.1204246. PMID 11313921.
- "Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.". J. Immunol. 166 (12): 7219–28. 2001. doi:10.4049/jimmunol.166.12.7219. PMID 11390470.
- "Vav2 is required for cell spreading.". J. Cell Biol. 154 (1): 177–86. 2001. doi:10.1083/jcb.200103134. PMID 11448999.
- "Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.". Cell. Signal. 13 (7): 475–81. 2001. doi:10.1016/S0898-6568(01)00172-3. PMID 11516622.
- "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth.". J. Biol. Chem. 276 (52): 48679–92. 2002. doi:10.1074/jbc.M106759200. PMID 11606575.
- "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation.". Mol. Cell. Biol. 22 (8): 2487–97. 2002. doi:10.1128/MCB.22.8.2487-2497.2002. PMID 11909943.
- "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.". J. Biol. Chem. 278 (7): 5163–71. 2003. doi:10.1074/jbc.M207555200. PMID 12454019.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
External links
- Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.
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