Biology:VAV3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

VAV3 has been shown to interact with Grb2.

See also

• Actin
• Cytoskeleton
• GTPase

Further reading

• Hobert O; Schilling JW; Beckerle MC et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene 12 (7): 1577–81. PMID 8622875. 
• Tamma SM; Chirmule N; Yagura H et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood 90 (4): 1588–93. doi:10.1182/blood.V90.4.1588. PMID 9269777. 
• Trenkle T; Welsh J; Jung B et al. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays". Nucleic Acids Res. 26 (17): 3883–3891. doi:10.1093/nar/26.17.3883. PMID 9705494. 
• "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". Mol. Cell. Biol. 19 (11): 7870–85. 1999. doi:10.1128/mcb.19.11.7870. PMID 10523675. 
• "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene 245 (1): 139–149. 2000. doi:10.1016/S0378-1119(00)00026-3. PMID 10713454. 
• Zeng L; Sachdev P; Yan L et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. PMID 11094073. 
• Inabe K; Ishiai M; Scharenberg AM et al. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189–200. doi:10.1084/jem.20011571. PMID 11805146. 
• "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene 21 (50): 7720–7729. 2002. doi:10.1038/sj.onc.1205927. PMID 12400014. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Zakaria S; Gomez TS; Savoy DN et al. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members". J. Exp. Med. 199 (3): 429–434. doi:10.1084/jem.20031228. PMID 14757747. 
• Pearce AC; Senis YA; Billadeau DD et al. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen". J. Biol. Chem. 279 (52): 53955–53962. doi:10.1074/jbc.M410355200. PMID 15456756. 
• "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76". J. Biol. Chem. 280 (15): 15289–15299. 2005. doi:10.1074/jbc.M500275200. PMID 15708849. 
• "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity". Mol. Endocrinol. 20 (5): 1061–1072. 2006. doi:10.1210/me.2005-0346. PMID 16384856. 
• Dong Z; Liu Y; Lu S et al. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer". Mol. Endocrinol. 20 (10): 2315–2325. doi:10.1210/me.2006-0048. PMID 16762975.