Biology:VIS1
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Short description: Gene in the species Homo sapiens
 Generic protein structure example |
VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM[1][2] It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs.[3] Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.[4]
See also
- Long noncoding RNA
References
- ↑ "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene 6 (11): 2041–2047. November 1991. PMID 1682866.
- ↑ "Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame". Mol. Cell. Biol. 14 (3): 1743–1751. March 1994. doi:10.1128/MCB.14.3.1743. PMID 8114708.
- ↑ "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene 184 (2): 169–176. January 1997. doi:10.1016/S0378-1119(96)00591-4. PMID 9031624.
- ↑ "Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues". Am. J. Pathol. 150 (4): 1297–1305. April 1997. PMID 9094986.
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