Biology:VPS28

Generic protein structure example

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.

Function

This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.

Interactions

VPS28 has been shown to interact with TSG101.

Further reading

• "Protein sorting into multivesicular endosomes". Curr. Opin. Cell Biol. 15 (4): 446–55. 2004. doi:10.1016/S0955-0674(03)00080-2. PMID 12892785. 
• "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. 2001. doi:10.1074/jbc.M009863200. PMID 11134028. 
• "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. 2001. doi:10.1101/gr.180101. PMID 11591653. 
• "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. 2002. doi:10.1083/jcb.200112080. PMID 11916981. 
• "Role of ESCRT-I in Retroviral Budding". J. Virol. 77 (8): 4794–804. 2003. doi:10.1128/JVI.77.8.4794-4804.2003. PMID 12663786. 
• "Equine Infectious Anemia Virus Utilizes Host Vesicular Protein Sorting Machinery during Particle Release". J. Virol. 77 (15): 8440–7. 2003. doi:10.1128/JVI.77.15.8440-8447.2003. PMID 12857913. 
• "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. 2003. doi:10.1073/pnas.2133846100. PMID 14519844. Bibcode: 2003PNAS..10012414M. 
• "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. 2005. doi:10.1074/jbc.M405226200. PMID 15218037. 
• "The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation". Mol. Biol. Cell 15 (9): 4337–46. 2005. doi:10.1091/mbc.E04-03-0250. PMID 15240819. 
• "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. 2005. doi:10.1074/jbc.M410384200. PMID 15509564. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.