Biology:Vibrio cholerae ToxT activated RNAs
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In molecular biology, Vibrio cholerae ToxT activated RNAs are small RNAs which are produced by the bacterium Vibrio cholerae. They are regulated by the transcriptional activator ToxT and may play a role in V. cholerae virulence.[1] Two ToxT activated RNAs have been described: TarA (ToxT activated RNA A) and TarB (ToxT activated RNA B).
TarA
The TarA small RNA regulates PtsG, a glucose transporter involved in the regulation of glucose uptake. Regulation of PtsG by TarA may be dependent upon the Hfq protein, an RNA chaperone.[2]
TarB
TarB inhibits the expression of Toxin coregulated pilus biosynthesis protein F (TcpF). It does not act in conjunction with Hfq.[3]
See also
References
- ↑ "Non-coding sRNAs regulate virulence in the bacterial pathogen Vibrio cholerae.". RNA Biology 9 (4): 392–401. April 2012. doi:10.4161/rna.19975. PMID 22546941.
- ↑ "The Vibrio cholerae virulence regulatory cascade controls glucose uptake through activation of TarA, a small regulatory RNA.". Molecular Microbiology 78 (5): 1171–1181. December 2010. doi:10.1111/j.1365-2958.2010.07397.x. PMID 21091503.
- ↑ "A genome-wide approach to discovery of small RNAs involved in regulation of virulence in Vibrio cholerae.". PLOS Pathogens 7 (7): e1002126. July 2011. doi:10.1371/journal.ppat.1002126. PMID 21779167.
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