Biology:Vts1
From HandWiki
| Vts1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of Vts1p–SRE complex.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Vts1 | ||||||||
| Pfam | PF07647 | ||||||||
| SCOP2 | 1b0x / SCOPe / SUPFAM | ||||||||
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Vts1 is a post-transcriptional regulator that has RNA-binding Sterile alpha motif (SAM) domain.[2][3] The protein is found in Saccharomyces cerevisiae and several eukaryotes. In Saccharomyces the Vts1 impacts vesicular transport and sporulation.[4][5]
Interactions
Protein-protein interactions through SAM domains participate in different regulatory activities such as signal transduction. Proteins having such domains were also shown to recognize and interact with RNA structures of similar shape to the Smaug response element (SRE).[6] Vts1 binds to RNA targets that have CUGGC on hairpin loops.[7]
References
- ↑ "RNA recognition by the Vts1p SAM domain". Nature Structural & Molecular Biology 13 (2): 177–178. February 2006. doi:10.1038/nsmb1039. PMID 16429155.
- ↑ "SAM as a protein interaction domain involved in developmental regulation". Protein Science 6 (1): 249–253. January 1997. doi:10.1002/pro.5560060128. PMID 9007998.
- ↑ "Shape-specific recognition in the structure of the Vts1p SAM domain with RNA". Nature Structural & Molecular Biology 13 (2): 160–167. February 2006. doi:10.1038/nsmb1038. PMID 16429156.
- ↑ "Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences of the United States of America 99 (24): 15530–15535. November 2002. doi:10.1073/pnas.202604399. PMID 12432101. Bibcode: 2002PNAS...9915530D.
- ↑ "Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6". The Journal of Biological Chemistry 276 (37): 34537–34544. September 2001. doi:10.1074/jbc.M101551200. PMID 11445562.
- ↑ "SAM breaks its stereotype". Nature Structural Biology 10 (9): 677–679. September 2003. doi:10.1038/nsb0903-677. PMID 12942139. https://zenodo.org/record/1233554.
- ↑ "Shape-specific recognition in the structure of the Vts1p SAM domain with RNA". Nature Structural & Molecular Biology 13 (2): 160–167. February 2006. doi:10.1038/nsmb1038. PMID 16429156.
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