Biology:WIPF2

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.[1][2][3]

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.[3]

References

  1. Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210. 
  2. "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun 291 (1): 41–7. Feb 2002. doi:10.1006/bbrc.2002.6406. PMID 11829459. 
  3. 3.0 3.1 "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147179. 

Further reading