Biology:WNT2B
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Protein Wnt-2b (formerly Wnt13[1]) is a protein that in humans is encoded by the WNT2B gene.[2][3][4]
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.[4]
References
- ↑ "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development 130 (3): 587–98. 2003. doi:10.1242/dev.00244. PMID 12490564.
- ↑ "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene 13 (4): 873–6. Oct 1996. PMID 8761309.
- ↑ "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun 275 (1): 209–16. Sep 2000. doi:10.1006/bbrc.2000.3252. PMID 10944466.
- ↑ 4.0 4.1 "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7482.
Further reading
- Katoh M (2006). "WNT2B: comparative integromics and clinical applications (Review).". Int. J. Mol. Med. 16 (6): 1103–8. doi:10.3892/ijmm.16.6.1103. PMID 16273293.
- "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. 1994. doi:10.1091/mbc.4.12.1267. PMID 8167409.
- "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.". Genomics 46 (3): 450–8. 1998. doi:10.1006/geno.1997.5041. PMID 9441749.
- Katoh M (2002). "Differential regulation of WNT2 and WNT2B expression in human cancer.". Int. J. Mol. Med. 8 (6): 657–60. doi:10.3892/ijmm.8.6.657. PMID 11712082.
- "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. 2002. doi:10.1002/jcb.1257. PMID 11746496. https://zenodo.org/record/1229223.
- "Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs.". Endocrinology 143 (7): 2741–9. 2002. doi:10.1210/en.143.7.2741. PMID 12072409.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- Katoh M (2005). "Molecular evolution of Wnt2b orthologs.". Int. J. Oncol. 26 (4): 1135–9. doi:10.3892/ijo.26.4.1135. PMID 15754012.
- "Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites.". J. Biol. Chem. 281 (11): 7282–93. 2006. doi:10.1074/jbc.M511182200. PMID 16407296.
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