Biology:WT1-AS
From HandWiki
In molecular biology, WT1 antisense RNA (non-protein coding), also known as WT1-AS or WIT1, is a long non-coding RNA. In humans, it is found on chromosome 11 and is expressed in kidney.[1] It is transcribed in the opposite direction to the WT1 gene.[2] It is functionally imprinted in the human kidney, where only the paternal allele is expressed, but not in the foetal kidney.[3]
See also
- Long noncoding RNA
References
- ↑ "Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor.". Science 250 (4983): 991–994. 1990. doi:10.1126/science.2173145. PMID 2173145.
- ↑ "Sequence of the WT1 upstream region including the Wit-1 gene.". Genomics 17 (2): 499–501. 1993. doi:10.1006/geno.1993.1355. PMID 8406502. https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/2574.
- ↑ "Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor.". Cancer Res 60 (9): 2356–2360. 2000. PMID 10811108.
Further reading
- "A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.". Hum Mol Genet 16 (3): 343–354. 2007. doi:10.1093/hmg/ddl478. PMID 17210670.
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