Biology:XPNPEP2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.[1][2][3]
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.[3]
References
- ↑ "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta 1354 (1): 45–8. Dec 1997. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790.
- ↑ "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics 50 (1): 114–6. Apr 1999. doi:10.1006/geno.1998.5302. PMID 9628831.
- ↑ 3.0 3.1 "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7512.
Further reading
- "Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P". Biochem. Pharmacol. 44 (3): 479–87. 1992. doi:10.1016/0006-2952(92)90439-P. PMID 1510698.
- "The cloning and functional expression of human pancreatic aminopeptidase P". Biochem. Soc. Trans. 26 (3): S248. 1998. doi:10.1042/bst026s248. PMID 9765967.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene". Cytogenet. Cell Genet. 89 (1–2): 44–50. 2000. doi:10.1159/000015560. PMID 10894934.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–10. 2005. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors". Kidney Int. 70 (10): 1823–31. 2007. doi:10.1038/sj.ki.5001873. PMID 17003818.
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