Biology:YTHDF2

Generic protein structure example

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene.

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

See also

N⁶-Methyladenosine

Further reading

• "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
• "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. 2006. doi:10.1093/gerona/61.6.547. PMID 16799135. 
• "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. 2006. doi:10.1093/gerona/61.6.547. PMID 16799135. 
• "N6-methyladenosine-dependent regulation of messenger RNA stability". Nature 505 (7481): 117–20. 2014. doi:10.1038/nature12730. PMID 24284625. Bibcode: 2014Natur.505..117W. 
• "Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition". Cell Res. 24 (12): 1490–2. 2014. doi:10.1038/cr.2014.153. PMID 25412658. 
• "Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine". Cell Res. 24 (12): 1493–6. 2014. doi:10.1038/cr.2014.152. PMID 25412661. 
• "Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins". J. Biol. Chem. 290 (41): 24902–13. 2015. doi:10.1074/jbc.M115.680389. PMID 26318451. 
• "N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression". eLife 5. 2016. doi:10.7554/eLife.15528. PMID 27371828. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.